化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl piperidine-2-carboxylate → N-(2,4-dichloro-6-fluorobenzothiazol-7-yl)-perhydroimidazo[1,5-a]pyridine-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl piperidine-2-carboxylate | HCID 27517 | — |
| 反応物 | 2,4-Dichloro-6-fluoro-7-isocyanato-benzothiazole | HCID 11108157 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-(2,4-dichloro-6-fluorobenzothiazol-7-yl)-perhydroimidazo[1,5-a]pyridine-1,3-dione | HCID 19933463 | — |
反応手順
2.6 g Ethyl piperidine-2-carboxylate was added to a solution of 4.2 g 2,4-dichloro-6-fluoro-7-isocyanato-benzothiazole in 50 ml tetrahydrofuran. The mixture was heated for 5 hours under reflux. After cooling, the solvent was removed in vacuo and the residue recrystallised several times from ethyl acetate. Yield: 2.5 g=42% of theory m.p.: 168°-170° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05424443 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-599d75b7d02443e5b36146fca1375b02 |
| 出典メモ | uspto-grants-1995_06 |