Hydrochloric Acid → 1-(5-Bromopyrimidin-2-yl)cyclopropanamine dihydrochloride
反応式
C(OC(=O)[NH:7][C:8]1([C:11]2[N:16]=[CH:15][C:14]([Br:17])=[CH:13][N:12]=2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:19].O1CCOCC1>C(Cl)Cl>[ClH:19].[ClH:19].[Br:17][C:14]1[CH:15]=[N:16][C:11]([C:8]2([NH2:7])[CH2:9][CH2:10]2)=[N:12][CH:13]=1参加物
5
実験手順
[1-(5-Bromo-pyrimidin-2-yl)-cyclopropyl]-carbamic acid tert-butyl ester (1.18 g, 3.76 mmol) is dissolved in CH2Cl2 (5 mL) at room temperature. A 4M solution of HCl in dioxane (9.4 mL, 38 mmol) is added. After 2 hours, solvents are removed by a stream of N2 to afford crude title compound as a solid, which is used without purification (ES+ m/z 216.3).
後処理
- customsolvents are removed by a stream of N2
出典と根拠
- ORDレコード
- ord-6360d25c96c641328020d7c734517e23
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09056858B2
反応ノート
読み込み中…