3-(4-Cyano-3-fluorophenyl)-1-propene → 2-Fluoro-4-[2-(piperazin-1yl)ethyl]benzonitrile

反応式

[F:1][C:2]1[CH:9]=[C:8]([CH2:10][CH:11]=C)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].COC1C=C(CC[N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)C=CC=1C#N>>[F:1][C:2]1[CH:9]=[C:8]([CH2:10][CH2:11][N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

参加物

反応物 2

HCID 247217663-(4-Cyano-3-fluorophenyl)-1-propene

HCID 675169272-Methoxy-4-[2-(piperazin-1-yl)ethyl]benzonitrile

生成物 1

HCID 675159502-Fluoro-4-[2-(piperazin-1yl)ethyl]benzonitrile

実験手順

2-Fluoro-4-[2-(piperazin-1yl)ethyl]benzonitrile was prepared from 2-fluoro-4-(prop-2-en-1-yl)benzonitrile (described above) in an analogous fashion to that described for 2-methoxy-4-[2-(piperazin-1-yl)ethyl]benzonitrile.

出典と根拠

ORDレコード: ord-ecfe64f8682642aaa6bf4d175e6fa79f
出典データセット: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09056859B2

反応ノート

読み込み中…