Hydrochloric Acid → (3-Fluoro-2-nitrophenyl)acetic acid
反応式
[F:1][C:2]1[C:3]([N+:19]([O-:21])=[O:20])=[C:4]([CH:8](C(OCC)=O)[C:9]([O:11]CC)=[O:10])[CH:5]=[CH:6][CH:7]=1.Cl>O>[F:1][C:2]1[C:3]([N+:19]([O-:21])=[O:20])=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
A suspension of diethyl (3-fluoro-2-nitrophenyl)propanedioate (5.50 g, 18.3 mmol) in 40 mL of water was added 40 mL of concentrated hydrochloric acid and the mixture was refluxed for 5 hours. Cooled to room temperature, the mixture was extracted with EtOAc, dried over anhydrous sodium sulfate and concentrated to get crude (3-fluoro-2-nitrophenyl)acetic acid, which was used for next step without purification.
後処理
- temperaturethe mixture was refluxed for 5 hours
- extractionthe mixture was extracted with EtOAc
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-ef9fc0efe7eb4971b4433feb9dde59c0
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09056859B2
反応ノート
読み込み中…