5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine → 5-tert-Butyl-3-(2-chloro-pyridin-3-ylmethyl)-7-(3,3-difluoro-pyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

HRID 2173570ノート

反応式

HRID 2173570 の反応式
[C:1]([C:5]1[N:6]=[C:7]([N:16]2[CH2:20][CH2:19][C:18]([F:22])([F:21])[CH2:17]2)[C:8]2[N:13]=[N:12][N:11]([CH2:14][CH3:15])[C:9]=2[N:10]=1)([CH3:4])([CH3:3])[CH3:2].C(C1N=C(N2CCC(F)(F)C2)C2N=NNC=2N=1)(C)(C)C.Br.BrCC1[C:47]([Cl:52])=[N:48][CH:49]=[CH:50][CH:51]=1>>[C:1]([C:5]1[N:6]=[C:7]([N:16]2[CH2:20][CH2:19][C:18]([F:21])([F:22])[CH2:17]2)[C:8]2[N:13]=[N:12][N:11]([CH2:14][C:15]3[C:47]([Cl:52])=[N:48][CH:49]=[CH:50][CH:51]=3)[C:9]=2[N:10]=1)([CH3:2])([CH3:3])[CH3:4]

参加物

4

反応物 3

HCID 715582055-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidineHCID 895389403-(Bromomethyl)-2-chloropyridine hydrobromideHCID 178441789HCID 178441789、化合物

生成物 1

HCID 715588305-tert-Butyl-3-(2-chloro-pyridin-3-ylmethyl)-7-(3,3-difluoro-pyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

実験手順

In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 61), the title compound was prepared from 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 3-(bromomethyl)-2-chloropyridine hydrobromide and isolated as light-yellow gum. MS(m/e): 408.3 (MH+).

後処理

  1. customisolated as light-yellow gum

出典と根拠

ORDレコード
ord-44aa53674b034191b4088c5e814b20eb
出典データセット
uspto-grants-2015_06
特許番号
US09056866B2

反応ノート

読み込み中…