Triethylamine → (+/-)-1-Acetyl-4-acetylthio-2-pyrrolidone
反応式
[C:1]([N:4]1[CH2:8][C@H:7]([C:9](=[O:11])[CH3:10])[CH2:6][C:5]1=[S:12])(=[O:3])[CH3:2].C(N(CC)CC)C.S1C=CC=C1CC(O)=O>C(OCC)(=O)C>[C:1]([N:4]1[CH2:8][CH:7]([C:9](=[O:11])[CH3:10])[CH2:6][C:5]1=[S:12])(=[O:3])[CH3:2]参加物
5
実験手順
(+)-(4R)-1-Acetyl-4-acetylthio-2-pyrrolidone (3 g) and triethylamine (2.1 ml) are dissolved in ethyl acetate (30 ml), and the mixture is refluxed for three hours, and then allowed to stand at room temperature for 8 hours. To the reaction solution is added thiolacetic acid (1.2 ml), and the mixture is stirred at room temperature for 5 hours. The reaction solution is washed with water, dried, and evaporated to remove the solvent to give (±)-1-acetyl-4-acetylthio-2-pyrrolidone (2.7 g).
後処理
- temperaturethe mixture is refluxed for three hours
- washThe reaction solution is washed with water
- customdried
- customevaporated
- customto remove the solvent
出典と根拠
- ORDレコード
- ord-78b65f57d4cc4543959bfb9496b3572a
- 出典データセット
- uspto-grants-1995_06
- 特許番号
- US05424446
反応ノート
読み込み中…