Sodium Acetate → HCID 58442356、化合物

HRID 2173725ノート

反応式

HRID 2173725 の反応式
[CH2:1]([O:3][C:4](=[O:10])[CH:5]([NH2:9])[C:6](=[NH:8])[NH2:7])[CH3:2].[CH:11]([C:13]([C:15]([F:18])([F:17])[F:16])=O)=O.C([O-])(=O)C.[Na+]>O>[CH2:1]([O:3][C:4]([C:5]1[C:6]([NH2:7])=[N:8][C:13]([C:15]([F:18])([F:17])[F:16])=[CH:11][N:9]=1)=[O:10])[CH3:2]

参加物

5

反応物 3

HCID 517045Sodium AcetateHCID 27790243,3,3-Trifluoro-2-oxopropanalHCID 12439913HCID 12439913、化合物

生成物 1

HCID 58442356HCID 58442356、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a mixture of amino-carbamimidoyl-acetic acid ethyl ester (2 g, 9.22 mmol) and water (50 ml), a 20% aqueous solution of trifluoropyruvic aldehyde (2.32 g, 18.43 mmol) was added. To this mixture, sodium acetate (5.29 g, 64.52 mmol) was added (pH of the reaction mixture was pH5). The reaction mixture was left to stir at RT overnight. The resultant precipitate was filtered under vacuum purification by chromatography on silica eluting with iso-hexane:EtOAc (gradient of 0 to 10% EtOAc) afforded the title compound

後処理

  1. waitThe reaction mixture was left
  2. filtrationThe resultant precipitate was filtered under vacuum purification by chromatography on silica eluting with iso-hexane

出典と根拠

ORDレコード
ord-cd0c7e0b4cc241e5b7d2e9b0a01e57ec
出典データセット
uspto-grants-2015_06
特許番号
US09056867B2

反応ノート

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