[Br:1][C:2]1[C:3]([C:8]([CH3:12])([CH3:11])[C:9]#N)=[N:4][CH:5]=[CH:6][CH:7]=1.[H-].C([Al+]CC(C)C)C(C)C.Cl.C(=O)([O-])[OH:25].[Na+]>C1(C)C=CC=CC=1>[Br:1][C:2]1[C:3]([C:8]([CH3:12])([CH3:11])[CH:9]=[O:25])=[N:4][CH:5]=[CH:6][CH:7]=11.8 g of 2-(3-bromo-pyridin-2-yl)-2-methyl-propionitrile were dissolved in 20 ml of toluene. 5.9 ml of a 25% by weight toluene solution of diisobutylaluminum hydride were added thereto at 0° C. The mixture was stirred for 17 hours at room temperature. Subsequently, dilute hydrochloric acid was added thereto to dissolve the unreacted diisobutylaluminum hydride. Continuing, aqueous saturated sodium hydrogen carbonate solution was added thereto followed by extracting with ethyl acetate. The solvent of the organic phase was distilled off followed by purifying by silica gel column chromatography to obtain 0.44 g of 2-(3-bromo-pyridin-2-yl)-2-methyl-propioaldehyde.
読み込み中…
