Methanol → Methyl 4-fluoro-2-(trifluoromethyl)benzoate

HRID 217435

反応式

HRID 217435 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:3]=1.S(=O)(=O)(O)O.[CH3:20]O>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:20])=[O:7])=[C:4]([C:11]([F:12])([F:13])[F:14])[CH:3]=1

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 6882554-Fluoro-2-(trifluoromethyl)benzoic acid

生成物 1

HCID 15541084Methyl 4-fluoro-2-(trifluoromethyl)benzoate

実験手順

To a solution of 4-fluoro-2-(trifluoromethyl)benzoic acid in MeOH were added concentrated sulfuric acid at 0° C. The reaction mixture was heated and refluxed for 2 days. The reaction mixture was concentrated under reduced pressure and the residue was diluted with EtOAc. The organic layer was washed with a saturated aqueous NaHCO3 solution, dried over MgSO4, and then concentrated under reduced pressure to obtain methyl 4-fluoro-2-(trifluoromethyl)benzoate as a colorless oily substance.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperaturerefluxed for 2 days
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. additionthe residue was diluted with EtOAc
  5. washThe organic layer was washed with a saturated aqueous NaHCO3 solution
  6. dry with materialdried over MgSO4
  7. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-9d95e702b944488eba81ae0c24af7c6f
出典データセット
uspto-grants-2012_06
特許番号
US08193378B2

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