(-)-Isopulegol → Isopulegol, (+)-
反応式
[CH3:1][C@H:2]1[CH2:7][C@@H:6]([OH:8])[C@H:5]([C:9]([CH3:11])=[CH2:10])[CH2:4][CH2:3]1>O>[CH3:1][C@@H:2]1[CH2:7][C@H:6]([OH:8])[C@@H:5]([C:9]([CH3:11])=[CH2:10])[CH2:4][CH2:3]1参加物
3
試薬・触媒・溶媒 1
反応条件
- 温度
- 2.5 °C
実験手順
After the catalyst solution obtained in Example 34-1 was cooled to from 0 to 5° C., 1.54 g (10.0 mmol, optical purity: 96.6% e.e.) of 1-citronellal ((S)-citronellal) was added dropwise. The resulting mixture was stirred overnight at from 0 to 5° C. After completion of the reaction, 2 mL of water was added to the reaction mixture. The organic layer was analyzed using gas chromatography. As a result, it was found that a substrate conversion ratio was 89.2%, an isopulegol selectivity was 88.1%, and a d-n-isopulegol:(the other isomers) ratio was 96.9:3.1.
後処理
- additionwas added dropwise
- additionwas added to the reaction mixture
出典と根拠
- ORDレコード
- ord-79d33d735fd84177a5a8c7f08540813f
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09061959B2
反応ノート
読み込み中…