化工社化工社 化学情報印刷レポート · 研究参考用
HRID 217446作成日：2026年10月26日
[(4-Isobutylphenyl)ethynyl](trimethyl)silane → 5-Fluoro-7-((4-isobutylphenyl)ethynyl)-2H-chromene-3-carbaldehyde
https://huagongshe.com/reaction/217446
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | [(4-Isobutylphenyl)ethynyl](trimethyl)silane | HCID 58438693 | — |
| 反応物 | 5-fluoro-3-formyl-2H-chromen-7-yl trifluoromethanesulfonate | HCID 86657642 | — |
| 触媒 | Cupric Chloride | HCID 24014 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-Fluoro-7-((4-isobutylphenyl)ethynyl)-2H-chromene-3-carbaldehyde | HCID 58438685 | 23.8% |
反応手順
To a solution of copper chloride (10 mg) and Pd(PPh3)4 (60 mg) in DMF (2 mL) were added [(4-isobutylphenyl)ethynyl](trimethyl)silane (288 mg) and 5-fluoro-3-formyl-2H-chromen-7-yl trifluoromethanesulfonate (340 mg) at room temperature, followed by stirring at 80° C. for 12 hours. The reaction liquid was concentrated and the residue was purified by silica gel column chromatography (CHCl3) to obtain 5-fluoro-7-[(4-isobutylphenyl)ethynyl]-2H-chromene-3-carbaldehyde (83 mg) as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08193378B2 |
|---|
| 出典データセット | uspto-grants-2012_06 |
|---|
| ORD ID | ord-2d1d4fcb25d646269e27f1f81a42f442 |
|---|
| 出典メモ | uspto-grants-2012_06 |
|---|
