2-Iodo-3-methylbenzoic acid → Methyl 2-iodo-3-methylbenzoate
反応式
[I:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH2:12](Cl)Cl.CO>>[I:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:12])=[O:5]参加物
3
実験手順
2-iodo-3-methylbenzoic acid (595 mg, 2.27 mmol) was dissolved in DCM/MeOH=1/1 (5 ml) at 0° C., then TMS-CH2N2 (2M in Et2O, 1.4 ml, 2.8 mmol) was added. After 1.5 hours at RT solvents were evaporated. Yield 630 mg yellow oil.
後処理
- customAfter 1.5 hours at RT solvents were evaporated
出典と根拠
- ORDレコード
- ord-8262197c8ae54385a67703552e0e64e3
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09062033B2
反応ノート
読み込み中…