Potassium Carbonate → 3-Bromoquinolin-6-ol
反応式
C([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[CH:10][C:9]([Br:15])=[CH:8]2)(=O)C.C([O-])([O-])=O.[K+].[K+]>CO.O>[Br:15][C:9]1[CH:10]=[N:11][C:12]2[C:7]([CH:8]=1)=[CH:6][C:5]([OH:4])=[CH:14][CH:13]=2参加物
4
実験手順
A solution of Intermediate A (1 g, 3.76 mmol) and K2CO3 (1.04 g, 7.52 mmol) in MeOH/H2O (5 mL/3 mL) was stirred at rt for 2 hours. The reaction mixture was concentrated under reduced pressure to afford a crude solid which was further purified by washing with water, dried under vacuum to give the title compound as white solid (760 mg, yield 86%). LCMS (method N): [M+H]+=224, tR=2.29 min.
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure
- customto afford a crude solid which
- customwas further purified
- washby washing with water
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-0213db1a777843f58c9624f364cec839
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09062045B2
反応ノート
読み込み中…