Hydrochloric Acid → 4,6-Dimethylbenzo[d]isothiazole-3-carboxylic acid

HRID 2175177ノート

反応式

HRID 2175177 の反応式
[CH3:1][C:2]1[C:7]2[C:8]([C:11](N)=[O:12])=[N:9][S:10][C:6]=2[CH:5]=[C:4]([CH3:14])[CH:3]=1.[OH-:15].[K+].Cl>CCO.O>[CH3:1][C:2]1[C:7]2[C:8]([C:11]([OH:15])=[O:12])=[N:9][S:10][C:6]=2[CH:5]=[C:4]([CH3:14])[CH:3]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 584974364,6-Dimethyl-1,2-benzisothiazole-3-carboxylic acid amide

生成物 1

HCID 584973864,6-Dimethylbenzo[d]isothiazole-3-carboxylic acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

反応条件

温度
85 °C

実験手順

To a solution of 4,6-dimethyl-benzo[d]isothiazole-3-carboxylic acid amide (20 mg, 0.097 mmol) in EtOH (10 mL) and H2O (2 mL) was added KOH (11 mg, 0.19 mmol). The solution was heated to 85° C. for 48 hours. The solution was cooled and was placed in an ice bath. Conc. HCl was added to adjust the pH of the solution to 2. The solid that precipitated out from the solution was collected by filtration. The white solid was dried and was confirmed to be the title compound (15 mg, 75%).

後処理

  1. temperatureThe solution was cooled
  2. customwas placed in an ice bath
  3. customThe solid that precipitated out from the solution
  4. filtrationwas collected by filtration
  5. customThe white solid was dried

出典と根拠

ORDレコード
ord-c01df5994f6b44ff822cda85ad72a302
出典データセット
uspto-grants-2015_06
特許番号
US09062056B2

反応ノート

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