Methyl 3-(bromomethyl)benzoate → 4-Bromo-1-(3-methoxybenzyl)-1H-pyrazole

反応式

[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH2:7][C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=2)C(OC)=O)[CH:6]=1.BrCC1C=C(C=CC=1)[C:23](OC)=[O:24].BrCC1C=CC=C(OC)C=1>>[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH2:7][C:8]2[CH:17]=[CH:16][CH:15]=[C:10]([O:24][CH3:23])[CH:9]=2)[CH:6]=1

参加物

反応物 3

HCID 517981Methyl 3-(bromomethyl)benzoate

HCID 40672073-Methoxybenzyl bromide

HCID 17024610methyl 3-[(4-bromo-1H-pyrazol-1-yl)methyl]benzoate

生成物 1

HCID 551371064-Bromo-1-(3-methoxybenzyl)-1H-pyrazole

実験手順

The title compound was prepared using a procedure analogous to methyl 3-((4-bromo-1H-pyrazol-1-yl)methyl)benzoate except that methyl 3-(bromomethyl)benzoate was replaced with 1-(bromomethyl)-3-methoxybenzene. LCMS, [M+H]+=267.1.

出典と根拠

ORDレコード: ord-bd6674d54962448983920e40ece8e267
出典データセット: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09062028B2

反応ノート

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