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Trifluoroacetic anhydride → 2-Bromo-6-(hydroxymethyl)pyridin-3-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic anhydride | HCID 9845 | — |
| 反応物 | 2-Bromo-3-hydroxy-6-methylpyridine 1-oxide | HCID 56925650 | — |
| 生成物 | 2-Bromo-6-(hydroxymethyl)pyridin-3-ol | HCID 16044666 | — |
反応手順
A solution of 2-bromo-3-hydroxy-6-methylpyridine 1-oxide 29 (15 g, 0.075 mol) in TFAA (50 mL, 0.375 mol) and was stirred at 40° C. for 24 h. The solvent was removed under vacuum. The residue was purified by column chromatography (silica gel: EA:Hex, 2:1). Yield: 4.5 g, 30%. 1H NMR (CDCl3): δ 7.32 (d, J=8.0 Hz, 1H), 7.25 (d, J=8.5 Hz, 1H), 4.56 (s, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09062072B2 |
| 出典データセット | uspto-grants-2015_06 |
| ORD ID | ord-c68b22bfcca54895b6ac97f63476c008 |
| 出典メモ | uspto-grants-2015_06 |