Chloroform methanol → 2-(2-{2-[2-(2,2-Dimethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol

HRID 217552

反応式

HRID 217552 の反応式
[OH-].[Na+].CO.[CH3:5][O:6][CH:7]([O:25][CH3:26])[CH2:8][O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21]C(=O)C.C(Cl)(Cl)Cl.CO>CO>[CH3:26][O:25][CH:7]([O:6][CH3:5])[CH2:8][O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][OH:21]

参加物

5

反応物 3

HCID 21584188Chloroform methanolHCID 23721981Sodium hydroxide methanolHCID 59236850Acetic acid 2-(2-{2-[2-(2,2-dimethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethyl ester2 回

生成物 1

HCID 592368592-(2-{2-[2-(2,2-Dimethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol収率 76%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1 N NaOH/Methanol (1 ml) was added to a stirring solution of acetic acid 2-(2-{2-[2-(2,2-dimethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethyl ester (Compound 4) (110 mg, 0.34 mmol) in methanol (3 ml) at ambient temperature. The reaction was monitored by TLC (CHCl3/MeOH, 9:1) and was completed within 30 minutes. The solvent was evaporated and the residue purified by flash chromatography (CHCl3/MeOH, 9:1) to afford the product (73 mg, 76%) as a colourless oil.

後処理

  1. customThe solvent was evaporated
  2. customthe residue purified by flash chromatography (CHCl3/MeOH, 9:1)

出典と根拠

ORDレコード
ord-a6236d5da9ea486d949e7dc156ab0ff8
出典データセット
uspto-grants-2012_06
特許番号
US08197793B2

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