HCID 86706150、化合物 → HCID 86706155、化合物
反応式
[C:1]([O:5][C:6]([C:8]1([CH:16]=[CH2:17])[CH2:13][O:12][C:11]([CH3:15])([CH3:14])[O:10][CH2:9]1)=[O:7])(C)(C)[CH3:2].C(OC(C1(C(=O)C)COC(C)(C)OC1)=O)C>>[CH2:1]([O:5][C:6]([C:8]1([CH:16]=[CH2:17])[CH2:13][O:12][C:11]([CH3:15])([CH3:14])[O:10][CH2:9]1)=[O:7])[CH3:2]参加物
3
実験手順
Compound 99b was prepared in the same manner as 2,2-dimethyl-5-vinyl-[1,3]dioxane-5-carboxylic acid tert-butyl ester using 5-acetyl-2,2-dimethyl-[1,3]dioxane-5-carboxylic acid ethyl ester instead of 5-acetyl-2,2-dimethyl-[1,3]dioxane-5-carboxylic acid tert-butyl ester in 50% yield over 2 steps. 1H NMR (300 MHz, CDCl3) δ 1.31 (t, J=7.1 Hz, 3H), 1.41 (s, 3H), 1.46 (s, 3H), 4.10 (ABq, ΔδAB=0.44, JAB=11.9 Hz, 4H), 4.26 (q, J=7.1 Hz, 2H), 5.24 (d, J=17.4 Hz, 1H), 5.28 (d, J=10.9 Hz, 1H), 5.24 (dd, J=17.4, 10.9 Hz, 1H). LCMS (m/z) 237.0 [M+Na], Tr=2.14 min.
後処理
- customLCMS (m/z) 237.0 [M+Na], Tr=2.14 min.