Benzenesulfonic Acid → (S)-Zopiclone Besylate

HRID 217646

反応式

HRID 217646 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C@@H:11]2[N:20]([C:21]3[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][N:26]=3)[C:18](=[O:19])[C:13]3[N:14]=[CH:15][CH:16]=[N:17][C:12]2=3)=[O:9])[CH2:4][CH2:3]1.[C:28]1([S:34]([OH:37])(=[O:36])=[O:35])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>C(O)C>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C@@H:11]2[N:20]([C:21]3[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][N:26]=3)[C:18](=[O:19])[C:13]3[N:14]=[CH:15][CH:16]=[N:17][C:12]2=3)=[O:9])[CH2:4][CH2:3]1.[S:34]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)([O-:37])(=[O:36])=[O:35]

参加物

4

反応物 2

HCID 7371Benzenesulfonic AcidHCID 969472Eszopiclone

生成物 1

HCID 131729769(S)-Zopiclone Besylate収率 52%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
0 °C

実験手順

A reactor was charged with 0.123 g (S)-zopiclone. To the reactor was added 0.056 g benzenesulfonic acid. The reaction was agitated and charged with 17.2 g ethanol. The reaction was cooled to 0° C., and the reaction was allowed to stir for greater than one hour after a slurry appeared. The reaction mixture was filtered and washed once with 0.5 g ethanol, dried in vacuo at approximately 50° C. for approximately 6 h to yield the titled compound in 52% yield.

後処理

  1. stirringto stir for greater than one hour after a slurry
  2. filtrationThe reaction mixture was filtered
  3. washwashed once with 0.5 g ethanol
  4. customdried in vacuo at approximately 50° C. for approximately 6 h

出典と根拠

ORDレコード
ord-800d98d95cfe40568d76bfcb4c6ca8c5
出典データセット
uspto-grants-2012_06
特許番号
US08198278B2

関連ノート

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