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Toluene → N-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)(tert-butoxy)formamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Phthalic Anhydride | HCID 6811 | — |
| 反応物 | tert-Butyl carbazate | HCID 70091 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)(tert-butoxy)formamide | HCID 801162 | 104.1% |
反応手順
250 g of tert-butyl hydrazinecarboxylate was added to toluene (3 L) solution of 280 g of phthalic anhydride. Using a Dean-Stark water separator, the reaction mixture was heated under reflux for 3 hours. This was cooled to room temperature, the formed solid was taken out through filtration to obtain 516 g of crude tert-butyl (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)carbamate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08198281B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-10d819d63d1f48a2b6875ffefe059d2d |
| 出典メモ | uspto-grants-2012_06 |