1-Naphthyl Isothiocyanate → 1-Naphthalen-1-yl-3-[5-(3-nitro-phenoxy)-pentyl]-thiourea

HRID 217667

反応式

HRID 217667 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:14]=[CH:15][CH:16]=1)[O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][NH2:13])([O-:3])=[O:2].[C:17]1([N:27]=[C:28]=[S:29])[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][CH:18]=1>ClCCl>[C:17]1([NH:27][C:28]([NH:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][O:7][C:6]2[CH:14]=[CH:15][CH:16]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)=[S:29])[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 2

HCID 110801-Naphthyl IsothiocyanateHCID 690096135-(3-Nitro-phenoxy)-pentylamine

生成物 1

HCID 866252701-Naphthalen-1-yl-3-[5-(3-nitro-phenoxy)-pentyl]-thiourea収率 82.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 5-(3-nitro-phenoxy)-pentylamine (867 mg, 3.87 mmol) in dichloromethane (5 mL) was added 1-naphthyl isothiocyanate (788 mg, 4.26 mmol) at room temperature. The reaction mixture was stirred at room temperature overnight. After removal of the solvent, the residue was purified by silica gel column chromatography to give 1-naphthalen-1-yl-3-[5-(3-nitro-phenoxy)-pentyl]-thiourea (1.3 g, 3.18 mmol, 82%) as a yellow gel.

後処理

  1. customAfter removal of the solvent
  2. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-48fbc2bd796e4410a7f1f6e9ab493106
出典データセット
uspto-grants-2012_06
特許番号
US08198284B2

関連ノート

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