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HRID 2176753作成日：2026年10月26日

3-(Morpholin-4-yl)propanoic acid → (3aR,4S,7aR)-4-(3-morpholin-4-yl-propionyloxy)-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester

https://huagongshe.com/reaction/2176753

反応式

関与物質

役割名称HCID仕込み量
反応物3-(Morpholin-4-yl)propanoic acidHCID 410813—
反応物(3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl esterHCID 68276168—
生成物(3aR,4S,7aR)-4-(3-morpholin-4-yl-propionyloxy)-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl esterHCID 60142172—

反応手順

Synthesis in analogy to the General Method 1 starting from (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester and 3-morpholin-4-yl-propionic acid to yield (3aR,4S,7aR)-4-(3-morpholin-4-yl-propionyloxy)-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester. MS [M+H]=296 (ester elimination ion); RT=4.088 min; LC-MS Method III

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09067881B2
出典データセットuspto-grants-2015_06
ORD IDord-ae0c7bffba2b45b6a176912e70e34509
出典メモuspto-grants-2015_06