化工社化工社 化学情報印刷レポート · 研究参考用
3-(2-Fluoro-4-nitrophenoxy)-2,6-dimethyl-pyridine → 4-(2,6-Dimethyl-pyridin-3-yloxy)-3-fluoro-phenylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(2-Fluoro-4-nitrophenoxy)-2,6-dimethyl-pyridine | HCID 59287319 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(2,6-Dimethyl-pyridin-3-yloxy)-3-fluoro-phenylamine | HCID 59287321 | 99.8% |
反応手順
A solution of intermediate 9 (5.88 g, 22.44 mmol) in ethanol (200 ml) was hydrogenated at room temperature in the presence of palladium 10% on activated carbon (0.58 g) for 3 hours. The solids were filtered off and the filtrate was evaporated till dryness to yield intermediate 10 (5.20 g, >99%) that was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09067891B2 |
| 出典データセット | uspto-grants-2015_06 |
| ORD ID | ord-06082289c222429badbd3e3a6515fc3e |
| 出典メモ | uspto-grants-2015_06 |