Ammonia → 2-[4-(4-Methylpiperazin-1-yl)phenyl]acetamide

反応式

[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][C:15]([O:17]C)=O)=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[NH3:19]>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][C:15]([NH2:19])=[O:17])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1

参加物

反応物 2

HCID 222Ammonia

HCID 59903719Methyl 2-(4-(4-methylpiperazin-1-yl)phenyl)acetate

生成物 1

HCID 673828632-[4-(4-Methylpiperazin-1-yl)phenyl]acetamide収率 57%

実験手順

Methyl 2-(4-(4-methylpiperazin-1-yl)phenyl)acetate (0.45 g, 1.81 mmol) in methanolic ammonia (15 ml) was heated at 100° C. in a pressure bomb overnight. Excess MeOH was concentrated under reduced pressure to give the crude compound. This was washed with n-pentane and dried in vacuo to afford 0.24 g (57%) of 2-(4-(4-methylpiperazin-1-yl)phenyl)acetamide as a brown color solid.

後処理

concentrationExcess MeOH was concentrated under reduced pressure
customto give the crude compound
washThis was washed with n-pentane
customdried in vacuo

出典と根拠

ORDレコード: ord-49d30c181bb3402b960fb142477dfec5
出典データセット: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09067888B2

反応ノート

読み込み中…

参加物