Ammonia → HCID 21973937、化合物
反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([CH3:14])[CH2:8][C:9](OCC)=[O:10])=[CH:3][CH:2]=1.[NH3:15]>>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([CH3:14])[CH2:8][C:9]([NH2:15])=[O:10])=[CH:3][CH:2]=1参加物
3
実験手順
A solution of ethyl 3-(pyridin-4-yl)butanoate (0.50 g, 2.59 mmol) in methanolic ammonia (10 ml) was heated to 100° C. in a pressure bomb for 48 h. The solvent was evaporated under reduced pressure to afford the crude compound, which was washed with n-pentane and dried under reduced pressure to afford 0.2 g (47%) of 3-(pyridin-4-yl)butanamide as an off-white solid.
後処理
- customThe solvent was evaporated under reduced pressure
- customto afford the crude compound, which
- washwas washed with n-pentane
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-bae163c026e14c37a50e9d65809f4649
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09067888B2
反応ノート
読み込み中…