Potassium Carbonate → 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-amine

HRID 217691ノート

反応式

HRID 217691 の反応式
Br.[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([C:9]([NH2:12])=[N:10][N:11]=2)[N:8]=1.C(=O)([O-])[O-].[K+].[K+]>O>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([C:9]([NH2:12])=[N:10][N:11]=2)[N:8]=1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 866507946-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide

生成物 1

HCID 151078816-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-amine収率 30.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide (W2.001; 1.1 g) was taken up with a large amount of water and alkalized with saturated potassium carbonate solution. The solid which precipitated out was filtered off with suction and dried (388 mg). Repeated extraction of the mother liquor with dichloromethane, drying of the combined organic phases over sodium sulfate, filtration and concentration afforded a further 228 mg of product in total.

後処理

  1. customThe solid which precipitated out
  2. filtrationwas filtered off with suction
  3. customdried (388 mg)
  4. extractionextraction of the mother liquor with dichloromethane
  5. dry with materialdrying of the combined organic phases over sodium sulfate, filtration and concentration

出典と根拠

ORDレコード
ord-3f4d53f273924bc791e4569682cc93f6
出典データセット
uspto-grants-2012_06
特許番号
US08198272B2

反応ノート

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