Diethyl 2-(4-(4-methylpiperazin-1-yl)benzyl)-2-methylmalonate → 2-(4-(4-Methylpiperazin-1-yl)benzyl)propanoic acid
反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:26]=[CH:25][C:11]([CH2:12][C:13](C)([C:19](OCC)=O)[C:14]([O:16]CC)=[O:15])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1>Cl>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[CH:26]=[CH:25][C:11]([CH2:12][CH:13]([CH3:19])[C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)[CH2:6][CH2:7]1参加物
3
実験手順
A solution of diethyl 2-(4-(4-methylpiperazin-1-yl)benzyl)-2-methylmalonate (1.50 g, 4.29 mmol) in conc. HCl (10 ml) was stirred at 130-140° C. in a sealed tube for 18 h. The reaction mixture was concentrated and co-distilled with toluene to afford 700 mg (63.6%) of 2-(4-(4-methylpiperazin-1-yl)benzyl)propanoic acid as dark brown solid.
後処理
- concentrationThe reaction mixture was concentrated and co-distilled with toluene
出典と根拠
- ORDレコード
- ord-32c21fe4074e45b4909b13fa3f3e124d
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09067888B2
反応ノート
読み込み中…