HCID 22459185、化合物 → HCID 86623474、化合物
反応式
[C:1](OC(=NC1CCCCC1)NC1CCCCC1)([CH3:4])([CH3:3])[CH3:2].[Cl:21][C:22]1[CH:27]=[C:26]([CH2:28][C:29]([OH:31])=[O:30])[CH:25]=[CH:24][N:23]=1>C(Cl)Cl>[Cl:21][C:22]1[CH:27]=[C:26]([CH2:28][C:29]([O:31][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:30])[CH:25]=[CH:24][N:23]=1参加物
4
実験手順
Compound 2-tert-butyl-1,3-dicyclohexylisourea (650 mg, 2.30 mmol) was added to a solution of 2-(2-chloropyridin-4-yl)acetic acid (200 mg, 1.16 mmol) in DCM (5 ml) at room temperature. The reaction mixture was stirred for 24 h, filtered, washed with DCM (5 ml) and saturated sodium bicarbonate solution (10 ml). The solvent was evaporated in vacuum to afford 200 mg (77%) of tert-butyl 2-(2-chloropyridin-4-yl)acetate as a colorless liquid.
後処理
- filtrationfiltered
- washwashed with DCM (5 ml) and saturated sodium bicarbonate solution (10 ml)
- customThe solvent was evaporated in vacuum
出典と根拠
- ORDレコード
- ord-033ca147b90f4b19acc5b650a4a49525
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09067888B2
反応ノート
読み込み中…