Ammonia → HCID 66869527、化合物

反応式

[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[C:12]([CH2:14][C:15]([O:17]C)=O)[CH:11]=[CH:10][N:9]=2)[CH2:4][CH2:3]1.[NH3:19]>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[C:12]([CH2:14][C:15]([NH2:19])=[O:17])[CH:11]=[CH:10][N:9]=2)[CH2:4][CH2:3]1

参加物

反応物 2

HCID 222Ammonia

HCID 67382772HCID 67382772、化合物

生成物 1

HCID 66869527HCID 66869527、化合物収率 31%

実験手順

A solution of methyl 2-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)acetate (750 mg, 2.81 mmol) in methanolic ammonia (10 ml) was heated in a steel bomb at 90° C. for 72 h. The reaction mixture was cooled to room temperature, concentrated and dried in vacuum to afford the crude product. Purification by triturating with diethyl ether afforded 370 mg (31%) of 2-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)acetamide as a light brown color solid.

後処理

concentrationconcentrated
customdried in vacuum
customto afford the crude product
customPurification
customby triturating with diethyl ether

出典と根拠

ORDレコード: ord-2ac5e599c5ff4ea392a173141b015e22
出典データセット: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09067888B2

反応ノート

読み込み中…

参加物