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3-Methoxyacetophenone → (+-)-1-(3-Methoxyphenyl)ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methoxyacetophenone | HCID 11460 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (+-)-1-(3-Methoxyphenyl)ethanol | HCID 90902 | 86.1% |
反応手順
To a solution of 3-methoxyacetophenone (3 g; 20 mmol) in methanol (60 mL) is added sodium borohydride (1.13 g; 30 mmol) in four portions over one hour. The reaction is stirred at room temperature overnight, neutralized with saturated ammonium chloride, and extracted with ethyl acetate. The organics are separated, washed with water, and dried over magnesium sulfate. The solvent is removed to give 2.62 grams of 1-(3-methoxyphenyl)-ethanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09067897B2 |
| 出典データセット | uspto-grants-2015_06 |
| ORD ID | ord-f34503721ede4d6d87a5b746acb3f354 |
| 出典メモ | uspto-grants-2015_06 |