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5-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile → 5-(4-Chlorophenyl)-2-hydroxypyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile | HCID 2763910 | — |
| 溶媒 | Phosphoric Acid | HCID 1004 | — |
| 生成物 | 5-(4-Chlorophenyl)-2-hydroxypyridine | HCID 10262372 | 75.6% |
反応手順
A mixture of 3-cyano-5-(4-chlorophenyl)-2-pyridinone (4.6 g) and 85% H3PO4 (60 ml) was heated at reflux for 16 hours. The resulting mixture was cooled to room temperature, poured into ice/water and filtered yielding 3.1 g of 5-(4-chlorophenyl)-2-pyridinone as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728715 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-354b2e3cf6af4b84a2f7d3ebed5eb64d |
| 出典メモ | uspto-grants-1998_03 |