1-(3-Chlorophenyl)ethanone → Benzenemethanol, 3-chloro-alpha,alpha-dimethyl-
反応式
[CH3:1][Mg]Br.[CH3:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[CH:8]=1)=[O:6]>CCOCC>[Cl:13][C:9]1[CH:8]=[C:7]([C:5]([OH:6])([CH3:1])[CH3:4])[CH:12]=[CH:11][CH:10]=1参加物
4
実験手順
Methylmagnesium bromide (3.6 mL, 10.67 mmol, Aldrich, 3 M solution in ether) was added to a cooled (−10° C.) solution of 3-chloroacetophenone (1.5 g, 9.7 mmol) in anhydrous ether slowly over 30 min. After complete addition, the reaction mixture was slowly warmed to room temperature, stirred for 18 hours. Again cooled (−5° C.), than quenched with sat. ammonium chloride solution over 30 min. The reaction mixture was extracted with ether, dried, filtered and concentrated to afford 1.55 g of 2-(3-chlorophenyl)propan-2-ol.
後処理
- additionAfter complete addition
- temperatureAgain cooled (−5° C.)
- customthan quenched with sat. ammonium chloride solution over 30 min
- extractionThe reaction mixture was extracted with ether
- customdried
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-1adb0086d2fc49b899c743659e764a8b
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09067897B2
反応ノート
読み込み中…