Hydrochloric Acid → HCID 66924212、化合物

HRID 2177028ノート

反応式

HRID 2177028 の反応式
[Sn](Cl)Cl.Cl.[Cl:5][C:6]1[CH:24]=[CH:23][C:9]([O:10][CH2:11][C:12]2[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-])=O)[C:13]=2[C:14]#[N:15])=[CH:8][C:7]=1[CH3:25].[OH-].[K+]>>[NH2:20][C:16]1[CH:17]=[CH:18][CH:19]=[C:12]([CH2:11][O:10][C:9]2[CH:23]=[CH:24][C:6]([Cl:5])=[C:7]([CH3:25])[CH:8]=2)[C:13]=1[C:14]#[N:15]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 24479Stannous ChlorideHCID 66924453HCID 66924453、化合物

生成物 1

HCID 66924212HCID 66924212、化合物収率 88.9%

反応条件

温度
15 °C

実験手順

To a cooled (15° C.) and stirred solution of tin (II) chloride (0.37 g, 1.65 mmol) and con. hydrochloric acid (2.0 mL) was added a solution of 2-(4-chloro-3-methylphenoxymethyl)-6-nitrobenzonitrile (100.0 mg, 0.33 mmol). The reaction mixture was slowly warmed to room temperature and stirred for 3 hours. The reaction mixture was poured on to crushed-ice and potassium hydroxide solution, stirred, extracted with dichloromethane, filtered and dried to yield 80 mg of 2-amino-6-(4-chloro-3-methylphenoxymethyl)benzonitrile.

後処理

  1. temperatureThe reaction mixture was slowly warmed to room temperature
  2. additionThe reaction mixture was poured on
  3. stirringstirred
  4. extractionextracted with dichloromethane
  5. filtrationfiltered
  6. customdried

出典と根拠

ORDレコード
ord-550d240c77d74ce7b7145549e5b1f651
出典データセット
uspto-grants-2015_06
特許番号
US09067897B2

反応ノート

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