Potassium Hydroxide → Propane-1-sulfonic acid cyclopropyl-(2-hydroxy-ethyl)-amide

HRID 2177121ノート

反応式

HRID 2177121 の反応式
[CH:1]1([N:4]([S:11]([CH2:14][CH2:15][CH3:16])(=[O:13])=[O:12])[CH2:5][CH2:6][O:7]C(=O)C)[CH2:3][CH2:2]1.[OH-].[K+]>CO>[CH:1]1([N:4]([CH2:5][CH2:6][OH:7])[S:11]([CH2:14][CH2:15][CH3:16])(=[O:13])=[O:12])[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 59547802Acetic acid 2-[cyclopropyl-(propane-1-sulfonyl)-amino]ethyl ester

生成物 1

HCID 43577530Propane-1-sulfonic acid cyclopropyl-(2-hydroxy-ethyl)-amide収率 32.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of acetic acid 2-[cyclopropyl-(propane-1-sulfonyl)-amino]ethyl ester (1.7 g, 6.8 mmol) and KOH (0.57 g, 10.2 mmol) in 30 ml Methanol was stirred over night at room temperature. The solvent was evaporated the residue dissolved in ethyl acetate and subsequently extracted with water and 1 M KOH, dried over Na2SO4 and the solvent evaporated to obtain 0.46 g of product which was used purified by chromatography (253.5 mg of colorless oil)

後処理

  1. customThe solvent was evaporated the residue
  2. dissolutiondissolved in ethyl acetate
  3. extractionsubsequently extracted with water and 1 M KOH
  4. dry with materialdried over Na2SO4
  5. customthe solvent evaporated

出典と根拠

ORDレコード
ord-098e48aa23274b0582d1dabe0ca01b5c
出典データセット
uspto-grants-2015_06
特許番号
US09067871B2

反応ノート

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