HCID 12437435、化合物 → HCID 12437453、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]([OH:15])=[O:14])=[C:11](C(O)=O)[S:10][N:9]=2)=[CH:4][CH:3]=1>ClC1C=CC=CC=1Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]([C:13]([OH:15])=[O:14])=[CH:11][S:10][N:9]=2)=[CH:6][CH:7]=1参加物
3
反応条件
- 温度
- 200 °C
実験手順
Into a 50-mL round-bottom flask, was placed 3-(4-chlorophenyl)-1,2-thiazole-4,5-dicarboxylic acid (1.8697 g, 6.74 mmol, 1.00 equiv), 1,2-dichlorobenzene (20 mL). The resulting solution was stirred for 20 min at 200° C. The resulting mixture was concentrated, and then added 30 mL of petroleum ether slowly when it is hot. The solids were collected by filtration, washed with petroleum ether. This resulted in 1.35 g (86%) of 3-(4-chlorophenyl)-1,2-thiazole-4-carboxylic acid as a white solid.
後処理
- customInto a 50-mL round-bottom flask, was placed
- concentrationThe resulting mixture was concentrated
- additionadded 30 mL of petroleum ether slowly when it
- filtrationThe solids were collected by filtration
- washwashed with petroleum ether
- customThis resulted in 1.35 g (86%) of 3-(4-chlorophenyl)-1,2-thiazole-4-carboxylic acid as a white solid
出典と根拠
- ORDレコード
- ord-51aad4adf3bc4e138a695c90eaca1686
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09067898B1
反応ノート
読み込み中…