化工社化工社 化学情報印刷レポート · 研究参考用
Propionic Acid → 2-ethyl-1-phenyl-1H-imidazo[4,5-c]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Propionic Acid | HCID 1032 | — |
| 反応物 | 4-N-phenylpyridine-3,4-diamine | HCID 10583675 | — |
| 溶媒 | Phosphorus oxychloride | HCID 24813 | — |
| 生成物 | 2-ethyl-1-phenyl-1H-imidazo[4,5-c]pyridine | HCID 90409595 | 19.3% |
反応手順
A mixture of N4-phenylpyridine-3,4-diamine (8.0 g, 37.2 mmol), propionic acid (2.7 g, 37.2 mmol) and phosphorous oxychloride (50 mL) was stirred at reflux for 10 h. The reaction was purified by silica gel chromatography using ethyl acetate to afford the product as a solid (1.6 g, 19%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09066946B2 |
| 出典データセット | uspto-grants-2015_06 |
| ORD ID | ord-7cd3cb1fb65b4173a4000af600bf5e42 |
| 出典メモ | uspto-grants-2015_06 |