Hydrochloric Acid → HCID 68737958、化合物
反応式
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:10]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11]1)(=[O:3])[NH2:2].Cl>C(O)C>[NH:12]1[CH2:13][CH2:14][CH:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:1]([NH2:2])=[O:3])[CH2:11]1参加物
4
実験手順
Tert-butyl 3-(2-carbamoylphenyl)pyrrolidine-1-carboxylate, enantiomer 1 a1-5 (2.5 g, 8.61 mmol, 1 eq) is dissolved in ethanol (100 ml). A saturated solution of HCl in EtOH is added (10 ml). The reaction mixture is stirred for 20 h and evaporated to dryness to afford 1.64 g of 2-(pyrrolidin-3-yl)benzamide, enantiomer 1 a1-8 which is used in the next step without any further purification.
後処理
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-b4e27a80822b43b78353076b54b95d85
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09067930B2
反応ノート
読み込み中…