4-(8-methoxy-1-(1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole → 4-(8-methoxy-1-((S)-1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole

HRID 2178586ノート

反応式

HRID 2178586 の反応式
[CH3:1][O:2][C:3]1[C:12]([C:13]2[C:14]([CH3:19])=[N:15][O:16][C:17]=2[CH3:18])=[CH:11][C:10]2[N:9]=[CH:8][C:7]3[N:20]=[C:21]([CH:28]4[CH2:33][CH2:32][O:31][CH2:30][CH2:29]4)[N:22]([CH:23]([CH3:27])[CH2:24][O:25][CH3:26])[C:6]=3[C:5]=2[CH:4]=1>C(O)C>[CH3:1][O:2][C:3]1[C:12]([C:13]2[C:14]([CH3:19])=[N:15][O:16][C:17]=2[CH3:18])=[CH:11][C:10]2[N:9]=[CH:8][C:7]3[N:20]=[C:21]([CH:28]4[CH2:29][CH2:30][O:31][CH2:32][CH2:33]4)[N:22]([C@@H:23]([CH3:27])[CH2:24][O:25][CH3:26])[C:6]=3[C:5]=2[CH:4]=1

参加物

3

反応物 1

HCID 712589164-(8-methoxy-1-(1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole

生成物 1

HCID 712590474-(8-methoxy-1-((S)-1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole収率 44.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-(8-methoxy-1-(1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole (85 mg) was dissolved in ethanol (ca. 4 ml) with heating and sonication. Injections (400 μl) were then made via plastic syringe. The fractions between 24 min and 26.5 min were collected and the combined fraction solutions were evaporated to dryness using a rotary evaporator (30° C. bath temp). The residue was transferred to a tared glass vial using ethanol (ca 12 ml). The solvent was then removed by evaporation under a stream of nitrogen gas (room temp) to give 4-(8-methoxy-1-((S)-1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole (38 mg).

後処理

  1. temperaturewith heating
  2. customsonication
  3. customInjections (400 μl) were then made via plastic syringe
  4. customThe fractions between 24 min and 26.5 min were collected
  5. customthe combined fraction solutions were evaporated to dryness
  6. customa rotary evaporator (30° C. bath temp)
  7. customThe solvent was then removed by evaporation under a stream of nitrogen gas (room temp)

出典と根拠

ORDレコード
ord-d0485999d0c94aa7a9fa1dec8f425f22
出典データセット
uspto-grants-2015_06
特許番号
US09067936B2

反応ノート

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