[2-Bromo-4-(trifluoromethyl)benzyl]malonic acid → 3-(2-Bromo-4-(trifluoromethyl)phenyl)propanoic acid
反応式
[Br:1][C:2]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:3]=1[CH2:4][CH:5](C(O)=O)[C:6]([OH:8])=[O:7]>CCOCC>[Br:1][C:2]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:3]=1[CH2:4][CH2:5][C:6]([OH:8])=[O:7]参加物
3
実験手順
[2-Bromo-4-(trifluoromethyl)benzyl]malonic acid (9.80 g, 28.7 mmol) in a round-bottom flask was heated to 180° C. and heating was continued at 180° C. for 1.5 hrs. After cooling to room temperature, the solid was dissolved in ether. The resulting solution was dried over MgSO4 and concentrated. The solid was washed with hexane to give the title compound (7.20 g, 85%). MS calculated for C10H8BrF3O2: (M+H)+297; found 297.0, 299.0.
後処理
- temperatureheating
- dry with materialThe resulting solution was dried over MgSO4
- concentrationconcentrated
- washThe solid was washed with hexane
出典と根拠
- ORDレコード
- ord-5bb393760e0c41b481fb52ef83fce75f
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09067921B2
反応ノート
読み込み中…