Diethyl Ether → HCID 59212660、化合物
反応式
[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[F:12][C:13]([F:25])([F:24])[C:14]1[CH:22]=[C:21]2[C:17]([CH:18]=[CH:19][CH:20]2[OH:23])=[CH:16][CH:15]=1.CCOCC>C(Cl)Cl>[F:12][C:13]([F:24])([F:25])[C:14]1[CH:22]=[C:21]2[C:17]([CH:18]=[CH:19][C:20]2=[O:23])=[CH:16][CH:15]=1参加物
5
実験手順
To a solution of pyridinium chlorochromate (1.08 g, 5.0 mmol) in methylene chloride (15 mL) was added dropwise a solution of 6-(trifluoromethyl)-1H-inden-1-ol (500 mg, 2.498 mmol) in methylene chloride (10 mL). After being stirred for 14 h, ether (30 mL) was added, and the reaction mixture was filtered through silica gel. The filtrate was concentrated in vacuo. The crude material was chromatographed (10:1 hexane/EtOAc) to afford 200 mg (40%) of the product. LC-MS [M+1]=199.2.
後処理
- filtrationthe reaction mixture was filtered through silica gel
- concentrationThe filtrate was concentrated in vacuo
- customThe crude material was chromatographed (10:1 hexane/EtOAc)
出典と根拠
- ORDレコード
- ord-67288fb05b7b447cb094e9b7594a1b3a
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09067921B2
反応ノート
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