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Trifluoroacetic acid → HCID 178441789、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 71558053 | — |
| 生成物 | HCID 178441789 | HCID 178441789 | — |
反応手順
A mixture of 5-tert-butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine (264 mg, 656 μmol) and TFA (5.00 mL) was refluxed for 8 h under N2 atmosphere. The reaction mixture was concentrated in vacuo to afford crude to 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine. The residue was used for the next reaction without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09067943B2 |
| 出典データセット | uspto-grants-2015_06 |
| ORD ID | ord-813b3ca6840847548e0cea89acced488 |
| 出典メモ | uspto-grants-2015_06 |