Trifluoroacetic acid → HCID 178441789、化合物

HRID 2178995

反応式

HRID 2178995 の反応式
[C:1]([C:5]1[N:6]=[C:7]([N:23]2[CH2:27][CH2:26][C:25]([F:29])([F:28])[CH2:24]2)[C:8]2[N:13]=[N:12][N:11](CC3C=CC(OC)=CC=3)[C:9]=2[N:10]=1)([CH3:4])([CH3:3])[CH3:2].C(O)(C(F)(F)F)=O>>[C:1]([C:5]1[N:6]=[C:7]([N:23]2[CH2:27][CH2:26][C:25]([F:28])([F:29])[CH2:24]2)[C:8]2[N:13]=[N:12][NH:11][C:9]=2[N:10]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 715580535-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

生成物 1

HCID 178441789HCID 178441789、化合物

実験手順

A mixture of 5-tert-butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine (264 mg, 656 μmol) and TFA (5.00 mL) was refluxed for 8 h under N2 atmosphere. The reaction mixture was concentrated in vacuo to afford crude to 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine. The residue was used for the next reaction without further purification.

後処理

  1. temperaturewas refluxed for 8 h under N2 atmosphere
  2. concentrationThe reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-813b3ca6840847548e0cea89acced488
出典データセット
uspto-grants-2015_06
特許番号
US09067943B2

関連ノート

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