HCID 67312922、化合物 → HCID 9976826、化合物
反応式
Cl.[N:2]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[C@@H:4]([NH:10][C:11]([C:13]1[O:14][C:15]3[C:21]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=4[O:28][CH3:29])=[CH:20][CH:19]=[CH:18][C:16]=3[CH:17]=1)=[O:12])[CH2:3]2>C(OCC)(=O)C>[N:2]12[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9]1)[C@@H:4]([NH:10][C:11]([C:13]1[O:14][C:15]3[C:21]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=4[O:28][CH3:29])=[CH:20][CH:19]=[CH:18][C:16]=3[CH:17]=1)=[O:12])[CH2:3]2参加物
3
実験手順
600 mg (1.45 mmol) of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide hydrochloride (Example 102) are dissolved in 15 ml of ethyl acetate and extracted three times with 1N sodium hydroxide solution. The organic phase is dried over sodium sulphate and then concentrated. Drying under high vacuum results in 534 mg (97.6% of theory) of the title compound.
後処理
- extractionextracted three times with 1N sodium hydroxide solution
- dry with materialThe organic phase is dried over sodium sulphate
- concentrationconcentrated
- customDrying under high vacuum