Triethylamine → HCID 58111022、化合物
反応式
[CH3:1][C:2]1([CH3:22])[C@@H:5]([C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[O:7])[CH2:4][C@H:3]1[NH:14]C(=O)OC(C)(C)C.CCN(CC)CC>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:14][C@@H:3]1[CH2:4][C@H:5]([C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[O:7])[C:2]1([CH3:22])[CH3:1]参加物
4
実験手順
Tert-butyl (1R,3S)-2,2-dimethyl-3-(morpholine-4-carbonyl)cyclobutylcarbamate (Step 1, 0.260 g, 0.833 mmol) was taken in TFA:DCM (1:4) (3 ml) at 0° C.-room temperature and stirred for 1 hour. After completion of the reaction the solvent was evaporated and the crude dissolved in DCM and basified with Et3N (0.7 ml, 5.0 mmol). The resulting solution as such used for next reaction immediately. Wt: 0.176 g.
後処理
- customAfter completion of the reaction the solvent
- customwas evaporated
- dissolutionthe crude dissolved in DCM
- customThe resulting solution as such used for next reaction immediately
出典と根拠
- ORDレコード
- ord-5a5876f6a588474c8f65e636832d1790
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09067966B2
反応ノート
読み込み中…