Triethylamine → HCID 58111008、化合物
反応式
C(OC([NH:8][C@@H:9]1[CH2:12][C@H:11]([C:13]([NH:15][CH2:16][CH2:17][C:18]([O:20][CH3:21])=[O:19])=[O:14])[C:10]1([CH3:23])[CH3:22])=O)(C)(C)C.CCN(CC)CC>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:8][C@@H:9]1[CH2:12][C@H:11]([C:13]([NH:15][CH2:16][CH2:17][C:18]([O:20][CH3:21])=[O:19])=[O:14])[C:10]1([CH3:23])[CH3:22]参加物
4
実験手順
A stirred solution of methyl 3-((1S,3R)-3-(tert-butoxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)propanoate (step 1, 0.336 g, 1.024 mmol) in TFA:DCM (1:4) (4 ml) at 0° C.-room temperature for about 1 hour and after completion of the reaction, the solvent was evaporated and the crude dissolved in DCM and basified with Et3N (0.87 ml, 6.29 mmol) then the resulting solution as such used for the next reaction. Wt: 0.233 g (Based on 100% yield calculated and proceeded for next reaction).