Triethylamine → HCID 58111068、化合物
反応式
[CH3:1][C:2]1([CH3:21])[C@@H:5]([C:6]([N:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)=[O:7])[CH2:4][C@H:3]1[NH:13]C(=O)OC(C)(C)C.CCN(CC)CC>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:13][C@@H:3]1[CH2:4][C@H:5]([C:6]([N:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)=[O:7])[C:2]1([CH3:21])[CH3:1]参加物
4
実験手順
A solution of tert-butyl (1R,3S)-2,2-dimethyl-3-(pyrrolidine-1-carbonyl)cyclobutylcarbamate (step 1, 0.400 g, 1.351 mmol) in TFA:DCM (1:2) (3 ml) stirred at 0° C.-room temperature for about 1 hour. After completion of the reaction, the solvent was evaporated and the crude was dissolved in DCM and basified with Et3N (1.124 ml, 8.108 mmol) the resulting solution as such used for next reaction immediately. Wt: 0.264 g (Based on 100% yield calculated and proceeded for next reaction).
後処理
- customAfter completion of the reaction
- customthe solvent was evaporated
- dissolutionthe crude was dissolved in DCM
- customas such used for next reaction immediately
- customWt: 0.264 g (Based on 100% yield calculated and proceeded for next reaction)
出典と根拠
- ORDレコード
- ord-25748ac1e5c447498c5ca6faf5f9ad0d
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09067966B2
反応ノート
読み込み中…