Water → HCID 69799515、化合物

HRID 2179982ノート

反応式

HRID 2179982 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[O:9][C@@H:10]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:11][CH2:12]I.[NH2:20][CH2:21][CH2:22][CH2:23][OH:24].O>CN(C)C=O>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[O:9][C@@H:10]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:11][CH2:12][NH:20][CH2:21][CH2:22][CH2:23][OH:24]

参加物

5

反応物 3

HCID 962WaterHCID 90863-Amino-1-propanolHCID 69799252HCID 69799252、化合物

生成物 1

HCID 69799515HCID 69799515、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The product of step (b) (0.2 g) and 3-amino-propanol (0.11 g) were dissolved in dimethylformamide (4 ml) and stirred for 24 h. The reaction was poured into water and extracted into ethyl acetate. The organic extract was washed with brine, dried over magnesium sulphate and evaporated to dryness and triturated with 1N HCl in ether to give the product as a white solid.

後処理

  1. extractionextracted into ethyl acetate
  2. extractionThe organic extract
  3. washwas washed with brine
  4. dry with materialdried over magnesium sulphate
  5. customevaporated to dryness
  6. customtriturated with 1N HCl in ether

出典と根拠

ORDレコード
ord-99a4545c79eb4df79264a21932f1e55c
出典データセット
uspto-grants-2005_05
特許番号
US06887871B2

反応ノート

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