[2-Methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridin-3-yl]-hydrazine → 3-(3,5-Diethyl-pyrazol-1-yl)-2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridine

HRID 2180002ノート

反応式

HRID 2180002 の反応式
[CH3:1][O:2][C:3]1[C:8]([NH:9][NH2:10])=[CH:7][C:6]([CH3:11])=[C:5]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]([F:22])([F:21])[F:20])=[CH:14][C:13]=2[O:23][CH3:24])[N:4]=1>CCO>[CH2:7]([C:6]1[CH:5]=[C:12]([CH2:13][CH3:14])[N:9]([C:8]2[C:3]([O:2][CH3:1])=[N:4][C:5]([C:12]3[CH:17]=[CH:16][C:15]([O:18][C:19]([F:21])([F:22])[F:20])=[CH:14][C:13]=3[O:23][CH3:24])=[C:6]([CH3:11])[CH:7]=2)[N:10]=1)[CH3:8]

参加物

3

反応物 1

HCID 22490050[2-Methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridin-3-yl]-hydrazine

生成物 1

HCID 101814093-(3,5-Diethyl-pyrazol-1-yl)-2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Preparation of 3-(3,5-Diethyl-pyrazol-1-yl)-2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridine 3,5-heptane dione (0.32 ml, 2.33 mmol) is added to a solution of [2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridin-3-yl]-hydrazine (0.8 g, 2.33 mmol) in EtOH (15 ml) at room temperature. The mixture is refluxed for 15 hours. The solvent is removed under reduced pressure and the residue is purified by flash column chromatography to obtain 3-(3,5-Diethyl-pyrazol-1-yl)-2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridine (Compound 4). Rf(hexane/EtOAc=9:1)=0.18, MS m/z 436.4 (M+H).

後処理

  1. temperatureThe mixture is refluxed for 15 hours
  2. customThe solvent is removed under reduced pressure
  3. customthe residue is purified by flash column chromatography

出典と根拠

ORDレコード
ord-d08e34b4cbcf45219756d57e2faba052
出典データセット
uspto-grants-2005_05
特許番号
US06887875B2

反応ノート

読み込み中…