Diisobutylaluminumhydride → HCID 22490954、化合物
反応式
[F:1]/[C:2](=[C:8](/[C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][C:19]=1[O:20][CH2:21][CH2:22][CH3:23])[O:16][C:15]([CH3:25])([CH3:24])[CH:14]=[C:13]2[CH:26]([CH3:28])[CH3:27])\[CH3:9])/[C:3](OCC)=[O:4].[H-].C([Al+]CC(C)C)C(C)C>>[F:1]/[C:2](=[C:8](/[C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][C:19]=1[O:20][CH2:21][CH2:22][CH3:23])[O:16][C:15]([CH3:25])([CH3:24])[CH:14]=[C:13]2[CH:26]([CH3:27])[CH3:28])\[CH3:9])/[CH2:3][OH:4]参加物
3
実験手順
Following General Procedure L, ethyl (2E)-2-fluoro-3-(4-isopropyl-2,2-dimethyl-7-propoxy-2H-chromen-6-yl)-but-2-enoate (Compound 73, 130 mg, 0.33 mmol) and diisobutylaluminum hydride (1M in hexanes, 1.34 mL, 1.34 mmol) were reacted to give the title compound as a colorless oil after purification by flash chromatography (silica gel, 1:9 ethyl acetate/hexane).
後処理
- customwere reacted
出典と根拠
- ORDレコード
- ord-571dbe45b56a434ba8484f64bc844fea
- 出典データセット
- uspto-grants-2005_05