Vinylcyclopentane → (Z)-5-[2-cyclopentylethenyl]-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

HRID 2181352

反応式

HRID 2181352 の反応式
Br[C:2]1[C:10]2[C:9](=[O:11])[N:8]([CH3:12])[C:7](=[O:13])[N:6]([CH2:14][CH:15]([CH3:17])[CH3:16])[C:5]=2[S:4][C:3]=1[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]([F:28])([F:27])[F:26].[CH:29]1([CH:34]=[CH2:35])[CH2:33][CH2:32][CH2:31][CH2:30]1>>[CH:29]1(/[CH:34]=[CH:35]\[C:2]2[C:10]3[C:9](=[O:11])[N:8]([CH3:12])[C:7](=[O:13])[N:6]([CH2:14][CH:15]([CH3:17])[CH3:16])[C:5]=3[S:4][C:3]=2[CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[C:25]([F:28])([F:27])[F:26])[CH2:33][CH2:32][CH2:31][CH2:30]1

参加物

3

反応物 2

HCID 77345VinylcyclopentaneHCID 114429025-Bromo-1-isobutyl-3-methyl-6-[2-(trifluoromethyl)benzyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

生成物 1

HCID 69747927(Z)-5-[2-cyclopentylethenyl]-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

実験手順

Prepared using 5-bromo-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione and cyclopentyl-ethene. The crude product was purified by flash silica chromatography eluting with a gradient of 5-20% ethanol in dichloromethane to give the title compound as a yellow oil (0.17 g).

後処理

  1. customPrepared
  2. customThe crude product was purified by flash silica chromatography
  3. washeluting with a gradient of 5-20% ethanol in dichloromethane

出典と根拠

ORDレコード
ord-d511b31787344f8b89b4c6ae9c4185cf
出典データセット
uspto-grants-2005_05
特許番号
US06890923B2

関連ノート

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